Search results for " reproducibility"

showing 10 items of 77 documents

Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation.

2015

Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: O…

AdultMalemedicine.medical_specialtyAbdominal painConstipationConstipation severityChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational Health; Medicine (all)Reproducibility of ResultChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis Statistical; Public Health Environmental and Occupational HealthQuality of lifeInternal medicineSurveys and QuestionnairesmedicineCriterion validitySurveys and QuestionnaireHumansChronic constipationSettore MED/12 - Gastroenterologiabusiness.industryChronic constipationMinimal clinically important differenceMedicine (all)Environmental and Occupational HealthSettore MED/09 - MEDICINA INTERNAPublic Health Environmental and Occupational HealthReproducibility of ResultsStatisticalMiddle Agedmedicine.diseaseConfirmatory factor analysisSettore MED/18 - Chirurgia GeneraleChronic DiseasePhysical therapyQuality of LifeFunctional constipationChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Public Health Environmental and Occupational HealthChronic constipation; Chronic non-organic constipation; Constipation severity; Quality of life; Adult; Chronic Disease; Constipation; Female; Humans; Male; Middle Aged; Patient Care; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Factor Analysis StatisticalFemalePublic HealthChronic non-organic constipationPatient Caremedicine.symptombusinessFactor Analysis StatisticalFactor AnalysisConstipationHumanQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
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Validation and reproducibility of dietary assessment methods in adolescents: a systematic literature review.

2013

AbstractObjectiveThe aim of the present work was to determine what dietary assessment method can provide a valid and accurate estimate of nutrient intake by comparison with the gold standard.DesignA MEDLINE, EMBASE, ISI Web of Science, Cochrane and related references literature review was conducted on dietary assessment methods for adolescents reporting the validity and/or reproducibility values. A study quality assessment on the retrieved FFQ was carried out according to two different scoring systems, judging respectively the quality of FFQ nutrition information and of FFQ validation and calibration.SettingThe present review considered adolescents attending high schools and recruited in ho…

Pathologymedicine.medical_specialtyDietary assessmentAdolescentMEDLINEReproducibility of ResultMedicine (miscellaneous)Settore MED/42 - Igiene Generale E ApplicataDiet SurveysFood groupAdolescents; Dietary assessment; Reproducibility; Validation; Adolescent; Humans; Reproducibility of Results; Diet; Diet Surveys; Food Habits; Nutrition Assessment; Surveys and Questionnaires; Medicine (miscellaneous); Nutrition and Dietetics; Public Health Environmental and Occupational Health; Medicine (all)Environmental healthSurveys and QuestionnairesValidationNutrition and DieteticMedicineSurveys and QuestionnaireHumansNutrition informationReproducibilityNutrition and Dieteticsbusiness.industryMedicine (all)Public Health Environmental and Occupational HealthReproducibility of ResultsGold standard (test)Feeding BehaviorDiet SurveysReproducibilityDietDiet SurveySystematic reviewNutrition AssessmentDietary assessmentFood HabitbusinessHumanPublic health nutrition
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Implementation of Sample Pooling Procedure Using a Rapid SARS-CoV-2 Diagnostic Real-Time PCR Test Performed Prior to Hospital Admission of People wit…

2021

Reliability, accuracy, and timeliness of diagnostic testing for SARS-CoV-2 infection have allowed adequate public health management of the disease, thus notably helping the timely mapping of viral spread within the community. Furthermore, the most vulnerable populations, such as people with intellectual disability and dementia, represent a high-risk group across multiple dimensions, including a higher prevalence of pre-existing conditions, lower health maintenance, and a propensity for rapid community spread. This led to an urgent need for reliable in-house rapid testing to be performed prior to hospital admission. In the present study, we describe a pooling procedure in which oropharyngeal…

medicine.medical_specialtyHealth Toxicology and MutagenesisPoolingRT-PCRsample poolingSample (statistics)DiseaseReal-Time Polymerase Chain ReactionSensitivity and SpecificityIntellectual DisabilityIntellectual disabilitymedicineHumansDementiaHospital admission RT-PCR Sample pooling SARS-CoV-2 Sensitivity Hospitals Humans Real-Time Polymerase Chain Reaction Reproducibility of Results SARS-CoV-2 Sensitivity and Specificity COVID-19 Intellectual DisabilitySARS-CoV-2business.industryBrief ReportPublic healthRPublic Health Environmental and Occupational HealthCOVID-19Reproducibility of Resultssensitivitymedicine.diseaseHospitalsTest (assessment)hospital admissionEmergency medicineMedicineSample collectionbusinessInternational Journal of Environmental Research and Public Health
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Gold nanostar–polymer hybrids for siRNA delivery: Polymer design towards colloidal stability and in vitro studies on breast cancer cells

2017

To overcome the low bioavailability of siRNA (small interfering RNA) and to improve their transfection efficiency, the use of non-viral delivery carriers is today a feasible approach to transform the discovery of these incredibly potent and versatile drugs into clinical practice. Polymer-modified gold nanoconstructs (AuNCs) are currently viewed as efficient and safe intracellular delivery carriers for siRNA, as they have the possibility to conjugate the ability to stably entrap and deliver siRNAs inside cells with the advantages of gold nanoparticles, which can act as theranostic agents and radiotherapy enhancers through laser-induced hyperthermia. In this study, AuNCs were prepared by coat…

3003siRNA deliverySmall interfering RNAPolymersMetal NanoparticlesPharmaceutical ScienceGold Colloid02 engineering and technologyPolyethylene Glycol01 natural sciencesPolyethylene GlycolsGold Colloidchemistry.chemical_compoundDrug Delivery SystemsMCF-7 CellDrug StabilityCoatingRNA Small InterferingPolymerDrug Carrierchemistry.chemical_classificationDrug CarriersTumorLipoic acidGold nanostarPolymer021001 nanoscience & nanotechnologyColloidal goldMCF-7 Cells0210 nano-technologyDrug carrierHydrophobic and Hydrophilic InteractionsBreast NeoplasmHumanBiological AvailabilityReproducibility of ResultBreast NeoplasmsNanotechnologyPolyethylene glycolengineering.materialSmall InterferingTransfection010402 general chemistryCell LineHydrophobic and Hydrophilic InteractionMetal NanoparticleCell Line TumorAmphiphileHumansGene SilencingParticle SizeGold nanostarsReproducibility of ResultsGold nanostars; Lipoic acid; MCF-7; PEG; PHEA; siRNA delivery; Biological Availability; Breast Neoplasms; Cell Line; Tumor; Drug Carriers; Drug Delivery Systems; Drug Stability; Gene Silencing; Gold; Gold Colloid; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Metal Nanoparticles; Particle Size; Polyethylene Glycols; Polymers; RNA; Small Interfering; Reproducibility of Results; Transfection; 3003PHEAPEG0104 chemical scienceschemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoengineeringRNAGoldMCF-7Drug Delivery SystemInternational Journal of Pharmaceutics
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Chronic Apical and Nonapical Right Ventricular Pacing in Patients with High-Grade Atrioventricular Block: Results of the Right Pace Study

2018

Objective. The aim of the study was to compare the two approaches to chronic right ventricular pacing currently adopted in clinical practice: right ventricular apical (RVA) and non-RVA pacing. Background. Chronic RVA pacing is associated with an increased risk of atrial fibrillation, morbidity, and even mortality. Non-RVA pacing may yield more physiologic ventricular activation and provide potential long-term benefits and has recently been adopted as standard procedure at many implanting centers. Methods. The Right Pace study was a multicenter, prospective, single-blind, nonrandomized trial involving 437 patients indicated for dual-chamber pacemaker implantation with a high percentage of RV…

Genetics and Molecular Biology (all)Malemedicine.medical_specialtyArticle SubjectImmunology and Microbiology (all)Heart Ventricleslcsh:Medicine030204 cardiovascular system & hematologyBiochemistryGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineInternal medicinemedicine80 and overHumansIn patientSingle-Blind Method030212 general & internal medicineInterventricular septumProspective StudiesAtrioventricular BlockAgedAged 80 and overGeneral Immunology and Microbiologybusiness.industrylcsh:RCardiac Pacing ArtificialReproducibility of ResultsAtrial fibrillationGeneral MedicineVentricular pacingmedicine.diseaseIncreased riskmedicine.anatomical_structureHigh grade atrioventricular blockTreatment OutcomeBaseline characteristicsHeart failureArtificialCardiologyClinical StudyQuality of LifeCardiac PacingFemalebusinessAged; Aged 80 and over; Female; Heart Ventricles; Humans; Male; Prospective Studies; Quality of Life; Reproducibility of Results; Single-Blind Method; Treatment Outcome; Atrioventricular Block; Cardiac Pacing Artificial; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)BioMed Research International
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RepeatsDB in 2021: improved data and extended classification for protein tandem repeat structures

2020

The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein tandem repeats are ubiquitous in all branches of the tree of life. The accumulation of solved repeat structures provides new possibilities for classification and detection, but also increasing the need for annotation. Here we present RepeatsDB 3.0, which addresses these challenges and presents an extended classification scheme. The major conceptual change compared to the previous version is the hierarchical classification combining top levels based solely on structural similarity (Class > Topology > Fold) with two new lev…

Repetitive Sequences Amino AcidAcademicSubjects/SCI00010BiologíaStatistics as TopicProtein Data Bank (RCSB PDB)Computational biologyBiologyRepetitive SequencesGene Ontology; HEK293 Cells; HeLa Cells; Humans; Proteins; Reproducibility of Results; Statistics as Topic; User-Computer Interface; Databases Protein; Repetitive Sequences Amino Acid; Tandem Repeat SequencesDatabases03 medical and health sciencesAnnotationUser-Computer InterfaceProtein structureSimilarity (network science)Tandem repeatGeneticsDatabase IssueHumansDatabases ProteinCiencias Exactasdatabase030304 developmental biology0303 health sciencesHierarchy (mathematics)Protein030302 biochemistry & molecular biologyProteinsReproducibility of Resultscomputer.file_formatProtein Data BankClass (biology)proteinsAmino AcidComputingMethodologies_PATTERNRECOGNITIONGene OntologyHEK293 CellsclassificationTandem Repeat Sequencesprotein tandem repeat structures[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]computerHeLa CellsNucleic Acids Research
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Validity of needle core biopsy in the histological characterisation of mammary lesions

2006

Summary Over the last few years, there has been an enormous increase in the use of needle core biopsy (CB) for the histopathological characterisation of suspect lesions of the breast. The aim of this study was to verify the diagnostic reliability of CB by comparing the histological results obtained with the use of this technique with those obtained from the whole of the surgically resected specimen. We studied 198 out of 426 patients with clinically and/or radiologically suspect breast lesions. We found correspondence between the histological examination of the whole of the excised specimen and that of the CB in 94.9% of the cases of infiltrating carcinoma and in 71.4% of those involving du…

Pathologymedicine.medical_specialtyReproducibility of ResultBreast NeoplasmsSensitivity and SpecificityBreast cancerNeedle core biopsyRetrospective StudiemedicineCarcinomaHumansbreast carcinomahumanintermethod comparisonarticle; breast carcinoma; breast disease; carcinoma in situ; diagnostic accuracy; diagnostic value; histopathology; human; human tissue; intermethod comparison; intraductal carcinoma; major clinical study; needle biopsy; prediction; priority journal; reliability; sensitivity and specificity; validation process Biopsy Needle; Breast Neoplasms; Carcinoma Ductal Breast; Carcinoma Intraductal Noninfiltrating; Female; Humans; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity [EMTREE medical terms]Retrospective Studiesintraductal carcinomaHistological examinationreliabilitybusiness.industryBiopsy Needlevalidation process MeSH: Biopsy NeedleCarcinoma Ductal Breastbreast diseaseReproducibility of Resultscarcinoma in situneedle biopsypredictionGeneral Medicinemedicine.diseasemajor clinical studyPredictive valuehuman tissueCarcinoma Intraductal Noninfiltratingpriority journalhistopathologyEMTREE medical terms: articlediagnostic accuracyFemaleSurgerydiagnostic valueRadiologybusinessCore biopsyBreast NeoplasmThe Breast
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Examining the generalizability of research findings from archival data

2022

This research project benefitted from Ministry of Education (Singapore) Tier 1 Grant R-313-000-131-115 (to A. Delios), National Science Foundation of China Grants 72002158 (to H.T.) and 71810107002 (to H.T.), grants from the Knut and Alice Wallenberg Foundation (to A. Dreber) and the Marianne and Marcus Wallenberg Foundation (through a Wallenberg Scholar grant; to A. Dreber), Austrian Science Fund (FWF) Grant SFB F63 (to A. Dreber), grants from the Jan Wallander and Tom Hedelius Foundation (Svenska Handelsbankens Forskningsstiftelser; to A. Dreber), and an Research & Development (R&D) research grant from Institut Européen d'Administration des Affaires (INSEAD) (to E.L.U.). Dmitrii Dubrov, o…

research reliabilityMultidisciplinaryZA4050 Electronic information resourcesDASVDP::Matematikk og Naturvitenskap: 400M-PSI/06 - PSICOLOGIA DEL LAVORO E DELLE ORGANIZZAZIONIarchival data; context sensitivity; generalizability; reproducibility; research reliabilityResearch reliability generalizability archival data reproducibility context sensitivity:Ciências Sociais::Economia e Gestão [Domínio/Área Científica]archival dataZA4050Inequality cohesion and modernizationM-PSI/03 - PSICOMETRIAVDP::Medisinske Fag: 700Ongelijkheid cohesie en moderniseringcontext sensitivitygeneralizabilityreproducibilityWork Health and Performance
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Validation of a Model for Identification of Patients at Intermediate to High Risk for Complications Associated With Acute Symptomatic Pulmonary Embol…

2015

For patients with acute symptomatic pulmonary embolism (PE), the Bova score classifies their risk for PE-related complications within 30 days after diagnosis. The original Bova score was derived from 2,874 normotensive patients with acute PE who participated in one of six prospective PE studies.We retrospectively assessed the validity of the Bova risk model in normotensive patients with acute PE diagnosed in an academic urban ED. Two clinician investigators used baseline data for the model's four prognostic variables to stratify patients into the three Bova risk stages (I-III) for 30-day PE-related complications. Intraclass correlation coefficient (ICC) and the κ statistic were used to asse…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyPrognostic variableIntraclass correlationBlood PressureCritical Care and Intensive Care MedicineRisk AssessmentHeart RateInternal medicine80 and overmedicineVentricular FunctionHumansStage (cooking)AgedRetrospective StudiesAged 80 and overFramingham Risk Scorebusiness.industryTroponin IReproducibility of ResultsRetrospective cohort studyMiddle AgedPrognosismedicine.diseasePulmonary embolismSurgeryAcute Disease; Aged; Aged 80 and over; Blood Pressure; Female; Heart Rate; Humans; Male; Middle Aged; Prognosis; Pulmonary Embolism; Reproducibility of Results; Retrospective Studies; Risk Assessment; Spain; Troponin I; Ventricular Function Right; Pulmonary and Respiratory Medicine; Critical Care and Intensive Care Medicine; Cardiology and Cardiovascular MedicineRightSpainAcute DiseaseCohortVentricular Function RightFemalePulmonary EmbolismCardiology and Cardiovascular MedicineRisk assessmentbusinessChest
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Sociodemographic factors in fibromyalgia: results from the Italian Fibromyalgia Registry

2022

ObjectiveFibromyalgia (FM) is a chronic musculoskeletal pain syndrome of unknown aetiopathogenesis. Its development and maintenance are related to the interplay of biological, psychological, and contextual factors. Among the contextual factors, sociodemographic aspects are poorly elucidated. This study aimed to evaluate the relationships between sociodemographic/ clinical factors and symptom severity measures using a web-based registry of patients with FM.MethodsAdult patients with an ACR 2010/2011 diagnosis of FM underwent a clinical evaluation and were asked to complete questionnaires covering their sociodemographic data (gender, age, marital status, educational level), and disease-specif…

AdultMalesociodemographic factorsImmunologyReproducibility of ResultsSeverity of Illness IndexRheumatologysociodemographic factors.Surveys and QuestionnairesQuality of LifegenderImmunology and AllergyHumansFemalefibromyalgiaRegistriesChronic Painadult; female; humans; male; quality of life; registries; reproducibility of results; severity of illness index; sociodemographic factors; surveys and questionnaires; chronic pain; fibromyalgia
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